SPRAVATO® Treatment at AlyZion

Feel Like Yourself Again with SPRAVATO®

If traditional antidepressants haven't provided the relief you need, SPRAVATO® offers a modern, FDA-approved alternative for treatment-resistant depression. Administered as a nasal spray, this fast-acting treatment works differently than standard medications to help restore emotional balance. Under the expert care of AlyZion Psychiatry, SPRAVATO® gives individuals and families new hope on their mental health journey.

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Millions of Americans suffer from treatment-resistant depression

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What is SPRAVATO®?

SPRAVATO® (esketamine) CIII is the first and only FDA-approved prescription nasal spray for adults living with treatment-resistant depression (TRD). It is designed for adults who struggle with Major Depressive Disorder and have not found adequate relief after trying at least two different oral antidepressants. It is also prescribed alongside oral antidepressants to help treat depressive symptoms in adults experiencing acute suicidal thoughts or actions.

How SPRAVATO® Works

Unlike traditional oral antidepressants that target brain chemicals like serotonin or norepinephrine, SPRAVATO® works differently by acting as an NMDA receptor antagonist that targets glutamate a key chemical messenger in the brain thought to help regulate mood and well-being. By acting on glutamate pathways, SPRAVATO® helps restore neural connections in the brain to reduce depressive symptoms more rapidly than conventional therapies.

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What to Expect with SPRAVATO® Treatment at AlyZion

In-Clinic Administration: SPRAVATO® is a nasal spray that patients self-administer under the direct supervision of a healthcare provider at a certified REMS (Risk Evaluation and Mitigation Strategy) medical facility.

Observation Period: Because side effects can include temporary sleepiness (sedation), dissociation (feeling disconnected from oneself or reality), or increased blood pressure, patients are monitored for at least two hours after taking a dose before going home.

Flexible Treatment Plan: SPRAVATO® can be taken with or without an oral antidepressant, offering a flexible approach to symptom relief.

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SPRAVATO® FAQ

How do I know if I qualify for SPRAVATO®?

SPRAVATO® is an FDA-approved prescription nasal spray specifically for adults who have treatment-resistant depression (TRD)—meaning you have tried at least two or more conventional oral antidepressants without finding adequate relief. It is also approved for adults experiencing major depressive disorder with acute suicidal thoughts or actions. During your initial consultation, Dr. Gyamfi will conduct a detailed evaluation to determine if SPRAVATO® is the right fit for your mental health journey.

Can I take SPRAVATO® at home?

No. Because SPRAVATO® can cause temporary sedation, temporary blood pressure increases, and dissociation (feeling disconnected from your thoughts or surroundings), FDA guidelines require it to be self-administered in a certified medical facility like AlyZion Psychiatry. You will take the nasal spray under direct medical supervision and stay in our comfortable clinic during a 2-hour observation period before going home.

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What is the typical SPRAVATO® treatment schedule?

Treatment begins with an induction phase of two sessions per week for the first 4 weeks. During weeks 5 through 8, appointments usually transition to once a week. After the initial 8 weeks, Dr. Gyamfi will evaluate your progress to customize a maintenance schedule, which often involves sessions once every 1 to 2 weeks to sustain your improvements.

Will I need someone to drive me home after a SPRAVATO® session?

Yes. You must arrange for a trusted driver or transportation service to take you home following each treatment session. Because SPRAVATO® causes temporary sleepiness and alters reaction times, you should not drive, operate machinery, or engage in activities that require complete mental alertness until the following day after a restful night's sleep.